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何首乌饮对D半乳糖所致衰老大鼠下颌下腺β半乳糖苷酶表达的影响
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【制中药论文】作者：李俊玫 高福禄 葛志华 李俊颖【摘要】 目的 通过观察何首乌饮干预的衰老大鼠下颌下腺β半乳糖苷酶（βgal）表达的改变，探讨何首乌饮的抗衰老作用。方法 用D半乳糖制造衰老大鼠模型，何首乌饮的干预作用分治疗和预防两部分，检测β半乳糖苷酶活性，观察下颌下腺衰老细胞数目改变。结果 预防性实验部分：模型组衰老细胞数目多于正常组和各预防性用药组；治疗性实验部分：用药各组与自然恢复组相比，衰老细胞数目明显减少，其中治疗中剂量组最低。结论 何首乌饮具有抗模型大鼠下颌下腺细胞衰老的作用。
【关键词】 何首乌；D半乳糖；衰老大鼠；下颌下腺；β半乳糖苷酶
【Abstract】 Objective To investigate the apoptosis of submandibular glandular cells and the effects of Heshouwuyin on the expressions of βgalactosidase in submandibular glands of aging rats. Methods Dgalactose senescence model was adop
ted in this research. The effects of Heshouwuyi were divided into two parts: preventive and treatment experiment. The βgalactosidase activity was detected.Results Experimental part of the prevention, the number of the aging positive cel
ls in model submandibular glands was significantly higher than that of normal and p
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