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生物膜的保护剂海藻糖在冻干红细胞中的应用
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【西药学科研论文】【摘要】 海藻糖作为一种稳定的非还原性双糖，在细胞冷冻、干燥、冻干过程中对细胞活性有着良好的保护作用并已广泛 应用 于人血细胞的冻干。海藻糖以其异常的水合能力、独特的玻璃化转换和晶体转变行为及抗高温潮湿的特性受到密切关注，并成为细胞保存 研究 中首选的一种保护剂。海藻糖对细胞的保护机制、海藻糖导入哺乳细胞的实验 方法 以及红细胞对海藻糖负载的可能作用机制都是近几年细胞保存研究的热点，本文就以上几方面的进展详细进行论述。
【关键词】 生物膜保护剂；海藻糖； 冻干保存； 红细胞
Trehalose —A Biomembrane Protectant Applyied to Lyophilization of Human Red Blood Cells——Review
AbstractTrehalose, as a nonreducing disaccharide, plays a role in protecting the cytoactivity when the cells is freezing, drying or lyophilization. It has been a biomembrane protectant applied to lyophilization of human blood cells (platelets and erythrocytes), and from which astonishing results have been obtained. Having powerful hydration, distinctive vitrification transform and crystal transform and unique resistance of high temperature and humidification, trehalose is thought of a preferred protectant in the study of cell p
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