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五味子醇提物对小鼠老化模型脑神经递质的影响
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【西医学论文网】作者：苗明三 马霄 张广伟 王力男【摘要】 目的 探讨五味子醇提物对小鼠脑老化模型脑乙酰胆碱酯酶(AChE)、单胺类神经递质的影响。方法 小鼠颈背部皮下连续40 d注射5% D半乳糖造脑老化模型，另设空白对照组，皮下注射生理盐水。从第11天分别灌服相应药物，1次/d。于最后1次给药后2 h，小鼠断头取脑，测脑匀浆AChE活性和单胺类神经递质含量。结果 与模型组相比，大剂量组可显著降低模型小鼠脑AchE活力，显著提高脑去甲肾上腺素(NA)、多巴胺(DA)水平，明显提高5羟色胺(5HT)水平。结论 五味子醇提部位可调节中枢神经递质的合成,有利于学习记忆，有抗脑老化作用。
【关键词】 五味子醇提物;D半乳糖;脑老化;神经递质
【Abstract】 Objective To observe the effect of Schisandra Chinensis Baill distilled by ethanol on acetylcholinesterase and neurotransmitter in aged mice model induced by Dgalactose. Methods 5% Dgalactose saline solution was injected into neck back subcutaneous tissue of mice to make the aged mice model for 40 days. From the 11th day, mice were filled with big, small dosage of Schisandra Chinensis Baill distilled by ethanol, Naokangling troche and the same dosage of saline solution everyday respectively. The blank control group was given hypert
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